Download E-books The Shulgin Index, Volume 1: Psychedelic Phenethylamines and Related Compounds PDF

By Alexander Shulgin, Tania Manning, Paul F. Daley

Take into accout: Alexander Shulgin has positioned quite a lot of time into learning and documenting those compounds/substances, in the event you do certainly get pleasure from this booklet. Please be sure you buy. He lately suffered a stroke in 2010, and isn't strong financially. Please bear in mind this whilst having fun with this treasure.
Here is the account from Ann Shulgin:
And a spot to donate while you are able to achieve this, yet can't buy this gorgeous text.

The Shulgin Index is the most recent paintings through Alexander ("Sasha" Shulgin,
the world's such a lot prolific explorer of the chemistry and results of
psychedelic medicinal drugs.

The Index is a complete survey of the known
psychedelics, and may be released in volumes.

VOL 1:
"Psychedelic Phenethylamines and similar Compounds"
With OCR!

The first quantity presents:
- A structure-oriented survey of psychedelic phenethylamines,
amphetamines, phenylpiperazines, and different related compounds.
- remedies of 126 major compounds with exact actual properties,
synthesis and analytical chemistry, biochemistry, pharmacological
properties, and criminal prestige. absolutely referenced with over 2,000 citations.
- Sub-tables of lesser-studied structural homologues and analogues.
Over 1300 overall compounds covered.
- wide cross-referencing tables for swift position of key information.
- a useful source for researchers, physicians, chemists, and legislations enforcement.

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Extra info for The Shulgin Index, Volume 1: Psychedelic Phenethylamines and Related Compounds

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Zero mg/kg of (±)-DOM from sa tne (30) a wide stud of . .. . 4-positiOJl ,ult stituent was once ~f ysy~h~delic compounds confirmed that the lipophthoty of the anJSt'f.! i. J 1989). pnmary value in opting for 5-HT2 receptor affinity (Glennon (31) Patented as a CNS . (32) Synthesis (Sh I . stimulant (Shulgin, 1969). (33) research on lhe ~i~~~;o). . curtrzlll$ echiuu/ata (Fo t ormation items of TMA MEM MPM and ALEPH via ' , ' seretal. ,l992). 122 . kilos sychede! Jc Phenetlzylamilzcs m1d Relatt'd Com Tile Shulgin Index _ p DOM ·s (Trachsel, 2003). d (22) Synlh e~t. HT eceptors was once measured and examine to slructtJrally relat d (23) The affin1ty to five- 2 r e cornPou nine eta]. , 19 0). f-IT d five HT · t · Seggel ( -. un-~an 5·HT? , five- 2c sera onm receptors used to be 2w an affinity to c1oned 1 • "" 2A ' nll'asu..... a (24) Tl1 e turally similar compounds (Nelson et al. , 1999). '"\! in comparison to struc Biochemistry · (Tacker, 1969) In th . of DOMin the rat in comparison wt·tl1 that o f tyramme Metab o11sm th . · period rimary metabolic assault used to be upon the 4-me yl crew; m 24 hours, 50% used to be excreted boHM (free and conjugated), 28% a_s D? CA, and eight% was once e~creted unchanged (Hoet ). A lrace of the oxidation deamtnation product 1-(2,5-dimethoxy-4-methylphen . 1971 propiophenone was once current (J-:Io et al. , 1971; Ho and Tansey, 1971). 4 possiblemetaboJiof DOM synthesized: 1-(2,5-dimethoxy-4-methylphenyl)-2-propanone, 1-(2,5-dimethort -methylpheny1-2-propanol, 1-(2,5-dimethoxy-4-me~y lpl~en~l)-2-propanone oxime _ four N-HO-DOM (Coutts and Malicky, 1973b). within the :abb1t, ox1dati~n of the 4-methylgroup DOM to the carboxylic acid (DOCA) used to be the pnmary metabohc transformation, at a 40%; basically approximately 1% was once excreted unchanged (Matin et al. , 1974) in a research of stereochenuca: facets ofDOM metabolism following i. p. adtninistration to the rabbit. In rat and rabbit arrangements, DOM was once metabolized through 5-demethylation, 2-demethylation, and 2,5-b'demethylation (Zweig and Castagnoli, 1975, 1977; Castagnoli et al. , 1976). Spectra! and kinetic metabolic reports of the interplay of DOM and its N-hydroxy metabolite utilizcc rabbit liver microsomal arrangements (McGraw, 1977). within the rabbit and the guinea r·~ ur1nary metabolites have been DOHM, ilie ~-alcohol and ~-ketone as a result of deamination the oxidation of the propyl chain giving 2,5-dimethoxy-4-methyl benzoic acid, and t: oxidation of the 4-methyl crew to a carboxy staff. This latter compound, DOCA' the key metabolite (Nagamatsu et al. , 1978). DOM metabolically bis-demethylated 2,5-DES-Me-DOM Qacob et al. , 1979). interplay of optical isomers of DOM and N-HODOM with rabbit liver cytochrome P450 studied (McGraw and Castagnoli, 1981). ? OM affecte_d the metabolism of biogenic amines within the rat mind (Leonard/ 19~) . mi mteracted wrth serotonin turnover in rat mind and spinal wire (Anden et aJ. , 19! 4)- ~a examine of its metabo~c destiny, DOM was once chemically switched over to 5-hydroxy-2,6-dimethvhn· dole by means of demethylahon with HBr by way of therapy with base (Zweig and Castagno 1974). The metabolism of the R-and S-DOM have been in comparison to the dl-racemate in ratli\~ homo~enate (McGraw et al.

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